Metastatic malignant peripheral nerve sheath tumour to the oral cavity: A Case Report

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Metastatic malignant peripheral nerve sheath tumour to the oral cavity: A Case Report

Ajura AJ, Lau SH, Wan Mahadzir Wan Mustafa, Chye PY, Suryati M: Metastatic malignant peripheral nerve sheath tumour to the oral cavity: A Case Report. Mal. J. Oral Maxillofac. Surg. 2008; 6: 30–34.

Abstract: Malignant peripheral nerve sheath tumour (MPNST) is closely associated with neurofibromatosis 1. Usually the lesion will metastasize to the lung, other extrapulmonary common metastatic sites include bone, liver, lymph node and brain. A case of MPNST metastasized to the mandible is presented. A 36 year old Indian lady was referred for evaluation of a swelling on the right mandible which extended from the right lower first premolar to the right lower third molar tooth. The intra- oral mass was interfering with her speech and occlusion. Her past medical history revealed she was diagnosed with neurofibromatosis at the age of 18 years old. She was also presented with swelling and pain over right thigh for which a biopsy was carried out and reported as MPNST. An incisional biopsy was performed on the intra-oral growth and a metastatic MPNST was diagnosed. To date this is the first reported case of MPNST metastasized to the oral cavity.