Ten-year Review of Salivary Gland Tumours at Two Referral Centres in Malaysia

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Ten-year Review of Salivary Gland Tumours at Two Referral Centres in Malaysia

Kipli NP, Mustafa WM, Tay KK: Ten-year Review of Salivary Gland Tumours at Two Referral Centres in Malaysia. Mal. J. Oral Maxillofac. Surg. 2011; 9: 17–20.

Abstract: Objective: To determine the pattern of occurrence of salivary gland tumours in Hospital Umum Sarawak and Hospital Kuala Lumpur over ten years.

Design: Cross-sectional retrospective study.

Methods: Medical records of patients presenting with tumours of the salivary glands in the two centres from 2000 to 2009 were reviewed. Demographic, clinical and histologic information data was analysed.

Results: Overall there was higher frequency of malignant tumours (66.7%). Females were more frequently affected and 15/36 cases (41.7%) presented with malignant tumours. Indians (5.6%) showed low prevalence compared to Malays, Chinese and Bumiputera Sarawak. Bumiputera Sarawak were also more likely to present with malignant rather than benign salivary gland tumours with 8/10 tumours encountered being malignant.

Pleomorphic adenoma (30.6%) was the most common diagnosis. The most frequent malignancy was mucoepidermoid carcinoma (27.8%) followed by adenoid cystic carcinoma (16.6%) and adenocarcinoma not otherwise specified (13.9%), polymorphous low-grade adenocarcinoma, salivary duct carcinoma and carcinoma ex pleomorphic adenoma.

Majority of the tumours occurred on the maxilla/palate (21/36 cases) with malignant tumours comprising twice as many as benign tumours. Out of a total of 36 cases, only 4 cases involved the parotid glands.

Surgery was the primary mode of treatment followed by combination of surgery and radiotherapy. More than half the cases reported absence of disease upon last review. A third of the cases (11/36) were lost to follow-up.

Conclusion: Females showed higher frequency of salivary gland tumours with preponderance for malignant tumours. There is racial variation with Indians presenting with low prevalence. Pleomorphic adenoma and mucoepidermoid carcinoma are the most common benign and malignant salivary gland tumours respectively. The main treatment option is surgery for both benign and malignant tumours. The authors proposed a larger scale study including other centres and standardized histopathological reporting for a true relative frequency of the distribution.